Ken Inoue Selected Research

Pelizaeus-Merzbacher Disease

9/2019	Drug screening for Pelizaeus-Merzbacher disease by quantifying the total levels and membrane localization of PLP1.
1/2019	Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA.
6/2016	A splicing mutation of proteolipid protein 1 in Pelizaeus-Merzbacher disease.
7/2014	Three new PLP1 splicing mutations demonstrate pathogenic and phenotypic diversity of Pelizaeus-Merzbacher disease.
5/2014	Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
4/2014	Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine.
12/2013	Partial PLP1 deletion causing X-linked dominant spastic paraplegia type 2.
3/2013	Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease.
5/2012	Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease.
2/2012	Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.

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Ken Inoue Research Topics

Disease

20	Neoplasms (Cancer) 05/2022 - 04/2010
12	Pelizaeus-Merzbacher Disease 09/2019 - 10/2002
8	Colitis 10/2022 - 01/2011
7	Inflammation (Inflammations) 10/2022 - 01/2011
6	Polyps 11/2022 - 07/2013
6	Hemorrhage 01/2021 - 09/2010
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/2020 - 03/2011
5	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 09/2010
4	Stomach Neoplasms (Stomach Cancer) 08/2021 - 01/2021
4	Panic Disorder (Panic Attack) 04/2012 - 09/2007
3	Ulcerative Colitis 06/2022 - 01/2012
3	Esophageal Neoplasms (Esophageal Cancer) 05/2022 - 01/2019
3	Esophageal Squamous Cell Carcinoma 05/2022 - 03/2021
3	Body Weight (Weight, Body) 01/2022 - 05/2002
3	Adenoma (Adenomas) 01/2021 - 03/2014
3	Wounds and Injuries (Trauma) 07/2019 - 06/2011
3	Hereditary Spastic Paraplegia 12/2013 - 02/2006
2	Gastritis 01/2022 - 01/2019
2	Adenocarcinoma 01/2022 - 01/2021
2	Paraplegia (Spastic Paraplegia) 12/2021 - 07/2019
2	Leukoencephalopathies 12/2021 - 11/2011
2	Disseminated Intravascular Coagulation 08/2021 - 05/2021
2	Carcinoma (Carcinomatosis) 08/2021 - 05/2002
2	Rectal Neoplasms (Rectal Cancer) 01/2021 - 05/2019
2	COVID-19 01/2021 - 01/2021
2	Fibrosis (Cirrhosis) 12/2020 - 01/2011
2	Epilepsy (Aura) 11/2020 - 01/2019
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 02/2020 - 01/2019
2	Genomic Instability 01/2020 - 07/2006
2	Constipation 01/2020 - 01/2020
2	Neoplasm Metastasis (Metastasis) 01/2020 - 04/2013
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 05/2002
2	Schizophrenia (Dementia Praecox) 07/2019 - 11/2015
2	Neuroinflammatory Diseases 07/2019 - 01/2018
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 05/2012
2	Hypertension (High Blood Pressure) 05/2017 - 02/2017
2	Ulcer 12/2012 - 03/2011
2	Agoraphobia 04/2012 - 09/2007
2	Neuroleptic Malignant Syndrome 01/2010 - 08/2006
2	Mental Disorders (Mental Disorder) 05/2007 - 06/2003
2	Peripheral Nervous System Diseases (PNS Diseases) 02/2006 - 11/2005
1	Seizures (Absence Seizure) 09/2022
1	Sarcoma (Soft Tissue Sarcoma) 06/2022
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 05/2022
1	Cachexia 05/2022
1	Tics (Tic) 04/2022
1	Intellectual Disability (Idiocy) 03/2022
1	Hyperplasia 01/2022
1	Metaplasia 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 03/2022 - 10/2002
7	Pharmaceutical PreparationsIBA 01/2022 - 09/2007
4	CytokinesIBA 06/2022 - 02/2011
4	Indomethacin (Indometacin)FDA LinkGeneric 12/2012 - 02/2011
3	AnticoagulantsIBA 01/2022 - 01/2019
3	Messenger RNA (mRNA)IBA 01/2022 - 03/2011
3	Dextrans (Dextran)FDA Link 07/2020 - 05/2012
3	Biological ProductsIBA 07/2019 - 06/2003
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2014
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2021 - 01/2019
2	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2019
2	NucleotidesIBA 11/2020 - 07/2019
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 07/2020 - 05/2012
2	3-deazaneplanocinIBA 02/2020 - 01/2019
2	Menthol FDA Link 01/2020 - 03/2014
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 07/2006
2	Hemostatics (Antihemorrhagics)IBA 01/2019 - 09/2010
2	Hyaluronic Acid (Hyaluronan)IBA 07/2013 - 02/2011
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/2012 - 02/2011
2	CurcuminIBA 05/2012 - 11/2005
2	Hemoglobins (Hemoglobin)IBA 03/2009 - 09/2007
1	Peptides (Polypeptides)IBA 10/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 09/2022
1	Interleukin-8 (Interleukin 8)IBA 06/2022
1	Volatile Fatty AcidsIBA 05/2022
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 05/2022
1	Lansoprazole (Prevacid)FDA LinkGeneric 05/2022
1	1- (5- (2- fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl)- N- methylmethanamineIBA 05/2022
1	Proton Pump InhibitorsIBA 05/2022
1	Adenosine Triphosphatases (ATPase)IBA 05/2022
1	Fluorouracil (Carac)FDA LinkGeneric 05/2022
1	Esomeprazole (Nexium)FDA Link 05/2022
1	Dietary Fiber FDA Link 05/2022
1	guar gum (guaran)IBA 05/2022
1	TabletsIBA 04/2022
1	Actin-Related Protein 2IBA 03/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Dextran SulfateIBA 01/2022
1	Blood Glucose (Blood Sugar)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022

Therapy/Procedure

14	Lasers (Laser) 11/2022 - 01/2019
8	Drug Therapy (Chemotherapy) 06/2022 - 04/2013
6	Therapeutics 05/2022 - 02/2017
5	Endoscopes 04/2022 - 01/2019
4	Surgical Instruments (Clip) 11/2021 - 09/2010
2	Traction 11/2021 - 12/2020
2	Enema (Enemas) 07/2020 - 01/2011
2	Aftercare (After-Treatment) 05/2017 - 02/2017
2	Catheters 01/2014 - 05/2002